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谷胱甘肽(glutathione)是甘油醛磷脱氢酶的辅基,又是乙二醛酶及磷酸丙糖脱氢酶的辅酶,参与体内三羧酸循环及糖代谢,使人体获得高能量。它能激活各种酶,如体内的巯基(-SH)酶等,从而促进碳水化合物、脂肪及蛋白质代谢,也能影响细胞的代谢过程。本文就有关文献综述其在临床中的应用。 1 治疗糖尿病神经病变糖尿病神经变是糖尿病最常见的并发症之一。谷胱甘肽是一种细胞内重要的调节代谢物质,能提供巯基、半胱氨酸,维持细胞的正常代谢与保护细胞的完整性,并能结合亲电子基与自由基等有害物质,具抗脂质过氧化作用,可直接使自由基还原或促进超氧化物歧化酶合成。谷胱甘胱过氧化物酶能消除体内过氧化氢,并且可以预防体内羟基(-OH)的形成。高血糖可使组织谷胱甘肽代谢异常,导致谷胱甘肽依赖性H_2O_2降解机制受损害,从而使神经组织易受损伤。姚民秀等对28例糖尿病神经病变病人,在较好控制血糖的基础上,应用谷胱
Glutathione is a cofactor of glyceraldehyde-1-phosphate dehydrogenase and a coenzyme of glyoxalase and triose phosphate dehydrogenase. It participates in tricarboxylic acid cycle and glucose metabolism in the body, which makes the body obtain high energy. It can activate various enzymes, such as the body of the sulfhydryl (-SH) enzymes, which promote carbohydrate, fat and protein metabolism, but also affect the cell’s metabolic processes. This article reviews the literature about its clinical application. 1 Treatment of diabetic neuropathy Diabetic neuropathy is one of the most common complications of diabetes. Glutathione is an important intracellular regulation of metabolism, can provide thiol, cysteine, to maintain the normal metabolism of cells and protect the integrity of cells, and can bind electrophiles and free radicals and other harmful substances, with Anti-lipid peroxidation, can directly reduce free radicals or promote superoxide dismutase synthesis. Glutathione peroxidase eliminates hydrogen peroxide in the body and prevents the formation of hydroxyl groups (-OH) in the body. Hyperglycemia can lead to abnormal metabolism of glutathione, leading to impairment of the glutathione-dependent H 2 O 2 degradation mechanism and thus to nerve tissue damage. Yao Minxiu and other 28 cases of diabetic neuropathy patients, on the basis of better control of blood glucose, the application of glutathione