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目的 比较rhTNF -NB与rhIL -2胸腔内联合注射 ,治疗恶性胸腔积液与单纯应用rhTNF -NB的疗效和毒副反应 ,寻求高效低毒治疗恶性胸腔积液的方法 ,以提高晚期癌症患者的生活质量。方法 对符合治疗条件的 5 0例恶性胸腔积液患者采用随机分组研究方法 ,观察联合应用 (方法 :先尽量抽取胸腔积液 ,先后将rhTNF -NB 2 0 0万单位用生理盐水 2 0ml稀释和rhIL -2 2 0万单位用生理盐水 2 0ml稀释注入胸腔。为减轻局部反应 ,可加 2 %利多卡因 10ml一并注入。每周 2次 ,2周为一疗程。如疗程中胸腔积液消失 ,即停止治疗。)与单独应用 (方法同上 ,每次仅注入rhTNF -NB 30 0万单位 )的临床疗效和毒副反应。结果 联合组有效率为92 0 % ,对照组为 44 0 % ,两组有显著性差异 (P <0 0 5 )。副作用有发热、寒战、恶心、呕吐、胸痛、乏力、血球变化及一过性肝肾损害等 ,两组无显著性差异。结论 rhTNF -NB与rhIL -2联合应用协同作用 ,疗效肯定 ,方法简单 ,优于单药使用
Objective To compare the efficacy and side effects of rhTNF-NB and rhIL-2 combined intrathoracic injection in the treatment of malignant pleural effusion and rhTNF-NB alone, and to seek a highly effective and low-toxic method for the treatment of malignant pleural effusions to improve the treatment of patients with advanced cancer. Quality of Life. Methods 50 patients with malignant pleural effusions who met the treatment conditions were randomly divided into groups. The combined methods were used (methods: pleural effusion was extracted as much as possible, and then the rhTNF-NB 20000 units were diluted with normal saline 2.0 ml. The rhIL-2200 units were diluted with normal saline 2.0 ml and injected into the thoracic cavity.In order to reduce the local reaction, 2% lidocaine and 10 ml can be injected at the same time.2 times a week for 2 weeks is a course of treatment, such as pleural effusion during treatment. Disappearance of treatment is stopped.) Clinical efficacy and side effects were compared with those used alone (same method as above, only injecting rhTNF-NB 300,000 units at a time). Results The effective rate in the combined group was 92.0% and 44.0% in the control group. There was a significant difference between the two groups (P < 0.05). Side effects include fever, chills, nausea, vomiting, chest pain, fatigue, changes in blood cells, and transient liver and kidney damage. There was no significant difference between the two groups. Conclusion The synergistic effect of rhTNF-NB and rhIL-2 combined therapy is positive, simple and superior to monotherapy.