目的　了解丙型肝炎患者外周血 B细胞和 T淋巴细胞及其亚群的变化。方法　应用单克隆技术测定 38例丙型肝炎患者外周血 B细胞和 T淋巴细胞亚群的水平并以 35名健康人作对照。结果　丙型肝炎患者外周血 B细胞数显著地高于正常人 (P<0 .0 0 1)、CD3、CD4、CD4/ CD8显著低于正常人 (P<0 .0 1,P<0 .0 0 1)。结论　丙型肝炎患者为一种自身免疫调节异常的疾病。 Objective To investigate the changes of peripheral blood B lymphocytes and T lymphocytes in patients with hepatitis C and their subgroups. Methods Monoclonal antibodies were used to determine the levels of B and T lymphocyte subsets in 38 patients with hepatitis C and 35 healthy controls. Results The number of B cells in peripheral blood of patients with hepatitis C was significantly higher than that of normal controls (P <0.01). The levels of CD3, CD4 and CD4 / CD8 in patients with hepatitis C were significantly lower than those in controls (P <0.01, P <0.01). 0 0 1). Conclusion Hepatitis C is a disorder with abnormal autoimmune regulation.