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缺氧诱导因子1(hypoxia-induciblefactor1,HIF-1)是机体对缺氧状态适应性反应的一种转录因子,它在恶性肿瘤的发生发展中起重要作用,本文复习近年来相关文献,就HIF-1的结构、调节、相关靶基因及在头颈部肿瘤的研究进展作一简要综述。
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that responds to hypoxia in the body. It plays an important role in the development of malignant tumors. In this paper, -1 structure, regulation, related target genes and research progress in head and neck cancer for a brief review.