Emerging nanozymes with natural enzyme-mimicking catalytic activities have inspired extensive research interests due to their high stability,low cost,and simple preparation,especially in the field of catalytic tumor therapy.Here,bio-breakable nanozymes based on glucose-oxidase (GOx)-Ioaded biomimetic Au-Ag hollow nanotriangles (Au-Ag-GOx HTNs) are designed,and they trigger an near-infrared (NIR)-Ⅱ-driven plasmon-enhanced cascade catalytic reaction through regulating tumor microenvironment (TME) for highly efficient tumor therapy.Firstly,GOx can effectively trigger the generation of gluconic acid (H+) and hydrogen peroxide (H2O2),thus depleting nutrients in the tumor cells as well as modifying TME to provide conditions for subsequent peroxidase (POD)-Iike activity.Secondly,NIR-Ⅱ induced surface plasmon resonance can induce hot electrons to enhance the catalytic activity of Au-Ag-GOx HTNs,eventually boosting the generation of hydroxyl radicals (·OH).Interestingly,the generated H2O2 and H+ can simultaneously induce the degradation of Ag nanoprisms to break the intact triangle nanostructure,thus promoting the excretion of Au-Ag-GOx HTNs to avoid the potential risks of drug metabolism.Overall,the NIR-Ⅱ driven plasmon-enhanced catalytic mechanism of this bio-breakable nanozyme provides a promising approach for the development of nanozymes in tumor therapy.