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应用ＬＳＡＢ免疫组织化学方法观察了ｎｍ２３基因产物／核苷二磷酸激酶（ｎｍ２３／ＮＤＰＫ）在喉鳞癌中的表达，结果喉鳞癌中ｎｍ２３／ＮＤＰＫ表达的阳性率为６９４％（２５／３６），相应的癌旁正常组织阴性。在与临床病理指标的相关性分析中发现无颈淋巴结转移者ｎｍ２３／ＮＤＰＫ表达的阳性率高于颈淋巴结转移者，差别有显著意义（Ｐ＜０．０５）；Ⅰ～Ⅱ期喉癌高于Ⅲ～Ⅳ期喉癌，差别也有显著意义（Ｐ＜０．０５）。ｎｍ２３／ＮＤＰＫ表达与病理分级无关，结果表明ｎｍ２３基因低表达与肿瘤进展及预后不良有关
The expression of nm23 / NDPK in laryngeal squamous cell carcinoma was observed by LSAB immunohistochemistry. The positive rate of nm23 / NDPK in laryngeal squamous cell carcinoma was 69.4% (25 / 36), the corresponding adjacent normal tissue negative. The positive rate of nm23 / NDPK expression in cervical lymph node metastasis was higher than that in cervical lymph node metastasis in the correlation analysis with clinicopathological parameters (P <0.05). The positive rate of nm23 / Ⅲ ~ Ⅳ laryngeal cancer, the difference is also significant (P <0.05). The expression of nm23 / NDPK was not correlated with the pathological grade. The results showed that the low expression of nm23 gene correlated with tumor progression and poor prognosis