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【目的】探讨单核细胞趋化蛋白-1(MCP-1)、巨噬细胞炎性蛋白(MIP-1α)在新生儿缺氧缺血性脑病(hy-poxic-ischemi cencephalopathy,HIE)中的意义。【方法】HIE新生儿40例(轻度20例,中度12例,重度8例)及30例正常对照新生儿采用ELISA法直接测定生后24～48h、7dMCP-1、MIP-1α数值。【结果】HIE组MCP-1生后24～48h(726.63±120.95)pg/mL、7d(380.47±80.72)pg/mL,较对照组(131.55±13.10)、(125.32±12.25)pg/mL均明显升高(P<0.05);HIE组MIP-1α生后24～48h(397.87±64.82)pg/mL、7d(230.7±42.73)pg/mL,较对照组2(114.7±10.37)、(110.50±10.21)pg/mL,均明显升高(P<0.05)。24～48h、7d存在动态变化,以24～48h较高(P<0.05)。HIE轻、中、重之间差异均有统计学意义(P均<0.05)。【结论】新生儿HIE血中MCP-1、MIP-1α水平高于正常新生儿,且其变化与时间及病变程度有关。
【Objective】 To investigate the expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein (MIP-1α) in neonatal hypoxic-ischemic encephalopathy (HIE) significance. 【Methods】 40 neonatal HIE neonates (mild 20, moderate 12, severe 8) and 30 normal newborn infants were measured by ELISA directly after 24 ~ 48h, 7dMCP-1, MIP-1α values. 【Results】 The plasma levels of MCP-1 in HIE group after 24-48 h (726.63 ± 120.95) pg / mL and 7 days (380.47 ± 80.72) pg / mL were significantly higher than those in control group (131.55 ± 13.10) and (125.32 ± 12.25) pg / (P <0.05). The levels of MIP-1α in HIE group after 24-48 h (397.87 ± 64.82) pg / mL and 7 days (230.7 ± 42.73) pg / mL were significantly higher than those in control group (114.7 ± 10.37) ± 10.21) pg / mL, were significantly higher (P <0.05). 24 ~ 48h, 7d there is a dynamic change to 24 ~ 48h higher (P <0.05). HIE light, moderate and heavy differences were statistically significant (P all <0.05). 【Conclusion】 The levels of MCP-1 and MIP-1α in neonates with HIE are higher than those of normal neonates, and the changes are related to the time and the degree of the disease.