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目的:研究粉防己碱(Tet)和尼莫地平(Nim)对吗啡在离体豚鼠回肠中戒断性反应的影响。方法:戒断性收缩由纳洛酮(1μmol·L~(-1))加入已在含吗啡(3μmol·L~(-1))的37.5℃ Krebs液中孵育4h的离体豚鼠回肠或加入从吗啡依赖豚鼠中取得的回肠引起。结果:离体豚鼠回肠在含吗啡的Krebs液中孵育4h,给Nim(0.01、0.05和0.1μmol·L~(-1))或Tet(1、10和50μmol·L~(-1))抑制其戒断性收缩。Nim和Tet体内或体外给药都能抑制吗啡依赖豚鼠离体回肠的戒断性收缩。结论:钙拮抗剂Nim和Tet抑制吗啡在离体豚鼠回肠的戒断性收缩。
AIM: To investigate the effects of tetrandrine (Nim) and nimodipine (Nim) on the withdrawal response of morphine in isolated guinea pig ileum. Methods: Contractile contractility was induced by the addition of naloxone (1 μmol·L -1) into the ileum of guinea pigs that had been incubated for 4 hours in 37.5 ℃ Krebs solution containing morphine (3 μmol·L -1) Ileum derived from morphine-dependent guinea pigs. Results: The ileum of guinea pigs were incubated in morphine-containing Krebs solution for 4 h, and were inhibited by Nim (0.01, 0.05 and 0.1 μmol·L -1) or Tet (1, 10 and 50 μmol·L -1) It abstinence contracts. Administration of Nim and Tet in vivo or in vitro both inhibited withdrawal withdrawal in morphine-dependent guinea pig ileum. CONCLUSION: Calcium antagonists Nim and Tet inhibit withdrawal withdrawal of morphine in isolated guinea pig ileum.