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目的探讨甲钴胺对慢性酒精中毒性周围神经病的治疗作用。方法健康成年日本大白兔40只,随机分为3组:安慰剂组、甲钴胺组和对照组。安慰剂组和甲钴胺组均以56°白酒按6ml·kg-1·d-1的剂量灌胃24周,对照组给予等体积生理盐水灌胃24周。24周后停止给酒,甲钴胺组给予甲钴胺注射液100μg·d-1,1次·d-1,肌注,连续4周;安慰剂组给予等体积生理盐水,1次·d-1,肌注,连续4周。4周后各组均行肌电图和坐骨神经病理检查。结果甲钴胺组家兔一般情况好于安慰剂组,肌电图和坐骨神经病理检查均显示周围神经病损害程度较安慰剂组轻。结论甲钴胺对慢性酒精中毒性周围神经病具有治疗作用。
Objective To investigate the therapeutic effect of mecobalamin on peripheral neuropathy of chronic alcoholism. Methods Forty adult Japanese white rabbits were randomly divided into three groups: placebo group, mecobalamin group and control group. Both placebo and mecobalamin groups were given gavage at a dose of 6 ml · kg-1 · d-1 for 24 weeks. The control group was given an equal volume of normal saline for 24 weeks. The rats in the mecobalamin group were given 100 μg · d-1 and 1 d · d -1 intramuscularly for 4 weeks. The rats in the placebo group were given equal volume of normal saline once a day -1, intramuscular injection for 4 weeks. After 4 weeks, EMG and sciatic nerve pathology were performed in all groups. Results The rabbits in the methylcobalamin group were generally better than the placebo group. EMG and sciatic nerve pathology showed that peripheral neuropathy lessened more than the placebo group. Conclusion Mecobalamin has a therapeutic effect on chronic alcoholic peripheral neuropathy.