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目的:探讨结直肠癌淋巴结微转移灶的特点及其临床病理意义。方法:对我院2001年1月-2006年10月收治的56例无组织学淋巴结转移的结直肠癌患者的650个淋巴结进行微转移灶的免疫组织化学和组织学检测,并分析微转移灶与患者临床病理特征之间的关系。结果:通过对4μm厚淋巴结连续切片进行观察,连续切片五片的微转移灶检出率较一片和两片的的微转移灶检出率显著升高(P<0.05)。按解剖部位分组的患者微转移灶阳性率1组有66.67%(16/24),2组有60%(9/15),3组有41.2%(7/17),无显著性差别(P>0.05)。微转移灶与无组织学淋巴结转移的结直肠癌患者的肿瘤浸润深度(P=0.013)和肿块大小(P=0.037)存在显著性相关,但有微转移灶和无微转移灶的无组织学淋巴结转移的结直肠癌患者总体生存状况比较无显著差异(P>0.05)。结论:微转移灶在无组织学淋巴结转移的结直肠癌淋巴结中较常见,与肿瘤大小和浸润深度有关,但与患者的预后无显著相关性。
Objective: To investigate the characteristics and clinicopathological significance of lymph node micrometastasis in colorectal cancer. Methods: Immunohistochemistry and histology were performed on 650 lymph nodes of 56 patients with colorectal cancer without histological lymph node metastasis from January 2001 to October 2006 in our hospital. And the clinicopathological features of the relationship between. Results: The detection rate of micrometastases in four consecutive slices was significantly higher than that in one and two micrometastases (P <0.05). The positive rate of micrometastases in group A was 66.67% (16/24) in group 1, 60% (9/15) in group 1, 41.2% (7/17) in group 3, and there was no significant difference (P > 0.05). There was a significant correlation between the depth of tumor invasion (P = 0.013) and tumor size (P = 0.037) in patients with colorectal cancer with micrometastases and without histological lymph node metastasis, but there was no difference between micrometastasis and micrometastasis The overall survival of colorectal cancer patients with lymph node metastasis was no significant difference (P> 0.05). Conclusions: Micrometastases are more common in lymph nodes with no histological lymph node metastasis, and are related to tumor size and depth of invasion, but have no significant correlation with the prognosis of patients.