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目的探讨维生素C联合环磷腺苷治疗小儿病毒性心肌炎的临床效果。方法选取收治的病毒性心肌炎患儿118例,随机分为两组,各59例。对照组给予常规治疗,观察组给予维生素C联合环磷腺苷治疗,对比两组治疗效果。结果观察组总效率高于对照组,差异显著(P<0.05);观察组治疗后TNF-α、IL-6、IL-8低于对照组,差异显著(P<0.05);观察组治疗后SOD、GSH-Px高于对照组,且MDA、CK、CK-MB、c Tn I水平低于对照组,差异显著(P<0.05)。结论维生素C联合环磷腺苷治疗小儿病毒性心肌炎疗效确切,可降低血清炎症因子水平,抗脂质过氧化,有效保护心肌细胞。
Objective To investigate the clinical effect of vitamin C combined with cyclic adenosine monophosphate on viral myocarditis in children. Methods 118 cases of children with viral myocarditis admitted to our hospital were randomly divided into two groups, 59 cases each. The control group was given routine treatment, and the observation group was given vitamin C combined with cyclic adenosine monophosphate. The therapeutic effect was compared between the two groups. Results The total efficiency of the observation group was significantly higher than that of the control group (P <0.05). The levels of TNF-α, IL-6 and IL-8 in the observation group were significantly lower than those in the control group The levels of SOD, GSH-Px were higher than those of the control group, and the levels of MDA, CK, CK-MB and cTnI were lower than those of the control group (P <0.05). Conclusion Vitamin C combined with cyclic adenosine monophosphate is effective in treating children with viral myocarditis. It can reduce the level of serum inflammatory cytokines and anti-lipid peroxidation and effectively protect myocardial cells.