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目的了解产妇乙肝标志物筛查情况及乙肝病毒(HBV)母婴阻断工作开展现状,评价乙型肝炎病毒表面抗原(HBs Ag)阳性产妇筛查及新生儿母婴阻断措施开展情况。方法在四川省彭州市和西充县选取2013-01-01/2014-03-31期间在医院产前筛查出的乙肝病毒表面抗原(HBs Ag)阳性住院分娩产妇及新生儿作为调查对象,开展流行病学调查。结果调查地区医疗机构产妇HBV血清学标志物筛查均采用国产酶联免疫吸附试验(ELISA)试剂,产妇HBs Ag阳性筛查率为5.18%,新生儿乙肝疫苗首针及时率为99.72%。随访的330名HBs Ag阳性产妇的新生儿均开展乙肝免疫球蛋白(HBIG)联合乙肝疫苗(Hep B)免疫策略,89.79%的新生儿接种10μg重组Hep B(酵母)。新生儿HBs Ag阳性率2.1%,乙肝病毒表面抗体(Anti-HBs)阳性率93.09%。不同喂养方式(χ~2=8.210,P=0.004)和母亲乙肝病毒e抗原(HBe Ag)产前不同检测结果(χ~2=4.500,P=0.034)对新生儿HBs Ag阳性率差异有统计学意义。结论调查地区HBV垂直传播母婴阻断措施实施效果显著,且不受喂养方式和分娩方式的影响,HBs Ag和HBe Ag双阳性和HBV DNA水平较高(>106 U/ml)孕妇应为母婴阻断的重点人群。
Objective To investigate the screening status of hepatitis B markers in maternal women and the current status of the prevention of hepatitis B virus (HBV) maternal and infant screening, evaluate the screening of HBs Ag positive maternal mothers and the neonatal maternal and neonatal obstructive measures. Methods Selected maternal and newborn fetuses with HBsAg positive hospitalized prenatal screening from 2013-01-01 / 2014-03-31 in Pengzhou City, Sichuan Province and Xiche County as the survey subjects, Conduct epidemiological investigation. Results Survey of HBV serology markers of maternal HBV-infected women in the local medical institutions adopted the domestic ELISA reagent. The positive screening rate of HBs Ag was 5.18% and the timely rate of the first needle of neonatal hepatitis B vaccine was 99.72%. All 330 neonates with positive HBsAg were followed up with Hepatitis B immunoglobulin (HBIG) and Hep B immunization strategies, and 89.79% of newborns were vaccinated with 10μg recombinant Hep B (yeast). The positive rate of neonatal HBsAg was 2.1%, and the positive rate of anti-HBs was 93.09%. The differences in the positive rates of HBsAg in neonates were statistically significant between different feeding methods (χ ~ 2 = 8.210, P = 0.004) and prenatal tests of mother’s hepatitis B virus e antigen (χ ~ 2 = 4.500, P = 0.034) Significance of learning. Conclusion The results showed that the effect of vertical blockage of HBV on mother-to-child transmission of HBV in the survey area was significant and independent of the mode of feeding and mode of delivery. Pregnant women with double positive HBsAg and HBeAg and high HBV DNA level (> 106U / ml) Infants blocked the focus of the crowd.