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目的 :研究HBVDNA在血清HBV标志阴性肝炎肝组织中的表达。方法 :对 4 5例HBV血清标志阴性肝炎患者 ,进行肝组织HBVDNA的原位杂交检测。结果 :原位杂交表明 ,HBVDNA阳性 7例 (阳性率 15 5 6 % ) ,阳性信号主要存在于肝细胞的胞核中 ,少数位于胞浆内 ;结论 :血清HBV标志阴性肝炎肝组织中可检出HBVDNA ,有利于提高对HBV感染的诊断
Objective: To study the expression of HBVDNA in liver tissue of patients with HBV-negative hepatitis. Methods: Forty-five HBV seronegative hepatitis patients were tested by in situ hybridization of HBVDNA in liver tissue. Results: In situ hybridization showed that HBVDNA positive in 7 cases (positive rate 15 5 6%), the positive signal mainly in the nucleus of hepatocytes, a few in the cytoplasm; Conclusion: serum hepatitis B virus hepatitis B flag-negative hepatitis A HBVDNA, help to improve the diagnosis of HBV infection