论文部分内容阅读
目的 观察不同水平牛磺酸对生长期大鼠和鸡脑神经递质代谢及脑发育的影响 ,探讨其在不同种属动物体中发挥生物效能的作用机制及特点。方法 采用幼鼠和雏鸡作为实验对象 :( 1)健康清洁级、断乳雌性SD大鼠 3 2只 ,按体重随机分为 4组。A组为对照组 ,B、C和D为 3个水平 (即 0 6% ,1 3 5 %和 3 % )牛磺酸补充组 ;( 2 )健康海兰褐壳蛋雏鸡 ( 1,3周龄 ) 4 0只 ,每个周龄组按体重随机分为 4组 ,A组为对照组 ,B、C、D为牛磺酸补充组 (即 0 12 % ,0 6%和 1 3 5 % )。结果 ( 1)牛磺酸能显著提高幼鼠和雏鸡脑牛磺酸积累和蛋白质水平 ,且呈现一定的剂量 -反应关系 ;( 2 )一定浓度的牛磺酸可增加雏鸡脑AChE的合成 ,但高于此范围则表现出抑制作用 ;( 3 )牛磺酸可抑制幼鼠和雏鸡脑 5 -HT和 5 -HIAA的合成。结论 牛磺酸能调节幼鼠和雏鸡脑某些神经递质的释放 ,且在不同种系动物对补充牛磺酸反应性不同。
Objective To observe the effects of different levels of taurine on the neurotransmitter metabolism and brain development in the developing rat and chicken brain and to explore its mechanism and characteristics of biological efficacy in different species of animal. Methods Young rats and chickens were used as experimental subjects: (1) 32 healthy female SD rats were randomly divided into 4 groups according to body weight. Group A was the control group, B, C and D were three levels (ie 0 6%, 1 35% and 3%) taurine supplementation group; (2) Age 40). Each week age group was randomly divided into 4 groups by body weight. Group A was the control group, while B, C and D were taurine supplementation group (ie, 0 12%, 0 6% and 1 35% ). Results (1) Taurine could significantly increase brain taurine accumulation and protein level in young rats and chickens, and showed a dose-response relationship. (2) Taurine at a certain concentration increased the synthesis of AChE in broiler brain, (3) Taurine inhibited the synthesis of 5-HT and 5-HIAA in neonatal rats and chickens. Conclusion Taurine can regulate the release of certain neurotransmitters in the brain of young and young chickens and has different reactivity to taurine supplementation in different germline animals.