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目的 :检测泰兴地区枯水期和丰水期不同水体的致突变性 ,并研究其与当地胃、食管和肝癌发生的相关关系。方法 :采用蚕豆根尖微核试验和慧星实验方法 ,检测泰兴市枯水期 97份和丰水期 10 1份水样的致突变性。结果 :水体致突变性呈塘水 >河水 >井水的规律 ;相同地区水体的致突变性在枯水期比丰水期强 ;枯水期河水和塘水诱发的微核效应与当地肝癌、胃癌和食管癌发病率有高度的正相关 ,而丰水期仅塘水微核效应与胃癌发病率有正相关 ;诱发微核率较高的井水、河水和沟塘水对人淋巴细胞都具有致突变性 ,其中尤以河水为甚。结论 :上述结果提示水源污染与肿瘤的高发可能存在着病因学联系
OBJECTIVE: To detect the mutagenicity of different waters in the dry and wet periods in Taixing, and to study the correlation between the mutagenicity and the local stomach, esophagus and liver cancer. Methods: Vicia faba root tip micronucleus test and comet assay were used to detect the mutagenicity of 97 samples in Taixing dry season and 10 1 samples in wet season. Results: The mutagenicity of water body showed the regularity of pond water> river water> well water. The mutagenicity of water body in the same area was stronger than that of wet season in dry season. The micronucleus elicited by river water and pond water in dry season was significantly correlated with local liver cancer, gastric cancer and esophageal cancer There was a positive correlation between the incidence of micronuclei in pond water and the incidence of gastric cancer. The well water with high micronucleus rate, river water and gully water had mutagenic effects on human lymphocytes Among them, the river is especially good. Conclusion: The above results suggest that there may be etiological relationship between water pollution and high incidence of cancer