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目的探讨氯吡格雷联合阿司匹林肠溶片治疗非ST段抬高急性心肌栵死的(NSTEMI)的安全性及临床效果。方法选取2007年1月-2010年1月期间NSTEMI患者116例,并随机分为观察组与对照组,每组各58例,对照组采用阿司匹林肠溶片治疗,观察组在对照组治疗的基础上加用氯吡格雷治疗。结果观察组总有效率为87.93%,对照组总有效率为58.62%,两组相比差异有统计学意义(P<0.05);两组用药前、后心电图ST段改变,血PT、APTT和PLT变化,其组内治疗前、后比较,差异有统计学意义(P<0.05);组间同期比较,差异有统计学意义(P<0.05)。结论氯吡格雷联合阿司匹林肠溶片治疗非ST段抬高急性心肌梗死能改善梗死血管畅通率,且有效降低血清心肌标记物,改善心电图及血液流变学指标。
Objective To investigate the safety and clinical efficacy of clopidogrel plus aspirin enteric-coated tablets in the treatment of non-ST elevation acute myocardial infarction (NSTEMI). Methods One hundred and sixteen patients with NSTEMI between January 2007 and January 2010 were selected and randomly divided into observation group and control group, 58 cases in each group. The control group was treated with aspirin enteric-coated tablets. The observation group was treated in the control group Plus clopidogrel treatment. Results The total effective rate was 87.93% in the observation group and 58.62% in the control group, with significant difference between the two groups (P <0.05). ST-segment changes, PT, APTT PLT changes in the group before and after treatment, the difference was statistically significant (P <0.05); between groups during the same period, the difference was statistically significant (P <0.05). Conclusion The combination of clopidogrel and aspirin enteric-coated tablets for non-ST segment elevation acute myocardial infarction can improve infarct vascular smoothness, reduce serum myocardial markers and improve electrocardiogram and hemorheology indexes.