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目的 :为探讨大剂量 PDD+5 - Fu动脉灌注治疗头颈部恶性肿瘤的疗效。方法 :用大剂量 PDD+5 - Fu经颞浅动脉灌注 ,治疗头颈部恶性肿瘤 ,并用同一方案 ,作静脉滴注 ,进行了前瞻性随机对比研究。结果 :动脉灌注组完全缓解(CR)为 47.2 % ,部分缓解 (PR)为 5 2 .7%。静脉滴注组 CR为 2 1.2 % ,PR为 72 .7%。两组疗效及副作用有显著性差异。结论 :认为大剂量 PDD+5 - Fu动脉灌注比大剂量静脉滴注疗效高 ,副作用小 ,是晚期头颈癌病人缓解病情 ,延长病人生存期的辅助方法之一。
Objective : To investigate the therapeutic effect of high-dose PDD+5 - Fu arterial infusion for the treatment of head and neck malignancies. METHODS: A large dose of PDD+5-Fu was injected through the superficial temporal artery to treat head and neck malignancies. The same protocol was used for intravenous drip and a prospective randomized controlled study was conducted. Results: The complete remission (CR) was 47.2% in the arterial infusion group, and the partial remission (PR) was 52.7%. Intravenous infusion group CR was 2 1.2% and PR was 72.7%. There was a significant difference in efficacy and side effects between the two groups. Conclusion : It is considered that high-dose PDD+5 - Fu intra-arterial infusion is more effective than high-dose intravenous infusion and has fewer side effects. It is one of the supplementary methods for patients with advanced head and neck cancer to relieve their disease and prolong their survival.