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目的检测ST13/HIP和Hsp70在子宫内膜癌、非典型增生和正常子宫内膜中的表达及相互关系。方法本院手术所取的良、恶性子宫内膜标本共132例为实验对象,采用免疫组织化学SP法检测ST13/HIP和Hsp70的表达水平。数据分析采用SPSS 13.0软件系统进行非参数检验(Krusral-Wallis H)方法及Kendall’s taur-b等级相关分析。P<0.05时表示差异有统计学意义。结果 ST13/HIP阳性表达在子宫内膜癌中高于非典型增生和正常子宫内膜(P<0.05);在Ⅲ、Ⅳ期子宫内膜癌组较Ⅰ、Ⅱ期组表达增高(P<0.05)。在子宫内膜癌中Hsp70阳性表达高于非典型增生和正常子宫内膜,差异有统计学意义(P<0.05),在不同临床手术病理分期子宫内膜癌组织中表达差异无统计学意义(P>0.05);在低分化子宫内膜癌组较中、高分化组表达增高(P<0.05)。在子宫内膜腺癌组织中ST13/HIP和Hsp70之间存在正相关,相关系数γ为0.298,P<0.05。结论 ST13/HIP和Hsp70在子宫内膜癌中存在过度表达,与肿瘤细胞生长及转移有关。两者之间表达呈正相关。
Objective To detect the expression and correlation of ST13 / HIP and Hsp70 in endometrial carcinoma, atypical hyperplasia and normal endometrium. Methods A total of 132 cases of benign and malignant endometrium taken from our hospital were selected as experimental subjects. The expression of ST13 / HIP and Hsp70 was detected by immunohistochemical SP method. Data Analysis The SPSS 13.0 software system was used for the non-parametric test (Krusral-Wallis H) and Kendall’s taur-b rank correlation analysis. P <0.05 means that the difference was statistically significant. Results The positive expression of ST13 / HIP in endometrial carcinoma was higher than that in atypical hyperplasia and normal endometrium (P <0.05), while it was higher in stage Ⅲ and Ⅳ endometrial carcinoma than in stage Ⅰ and Ⅱ (P <0.05) . The expression of Hsp70 in endometrial carcinoma was higher than that in atypical hyperplasia and normal endometrium (P <0.05), and there was no significant difference in the expression of Hsp70 in endometrial carcinoma between different clinicopathological stages ( P> 0.05). In poorly differentiated endometrial carcinoma group, the expression was higher than that in moderately and well differentiated group (P <0.05). There was a positive correlation between ST13 / HIP and Hsp70 in endometrial adenocarcinoma, the correlation coefficient γ was 0.298, P <0.05. Conclusion ST13 / HIP and Hsp70 are overexpressed in endometrial carcinoma, which is related to tumor cell growth and metastasis. There was a positive correlation between the two.