1955年Zollinger和EIIison报告胃酸分泌亢进、暴发性消化性溃疡病、伴有胰腺分泌非胰岛素的肿瘤;后来称叫卓-艾综合征.胃泌素瘤对这一病程命名则更确切.1987年ELLison等统计:在应用胃泌素放射免疫法测定前,80%患者有消化性溃疡病严重并发症和出血、梗阻、穿孔等.2/3以上患者在胃泌素瘤确诊前,至少经历过一次消化性溃疡病手术.胃泌素放射免疫法应用后,消化性溃疡病严重并发病者仅占20%,作 In 1955 Zollinger and EIIison reported hypersecretion of gastric acidity, fulminant peptic ulcer disease, non-insulin-secreting tumors with pancreatic secretion, and later called Charlie-Alzheimer’s syndrome. ELLison and other statistics: in the application of gastrin radioimmunoassay, 80% of patients with severe peptic ulcer complications and bleeding, obstruction, perforation, etc .. 2/3 above patients before the diagnosis of gastrinoma, at least experienced A peptic ulcer surgery. Gastrin radioimmunoassay, severe peptic ulcer disease and only 20% for