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1983年11月26～27日湖北省科学技术委员会和湖北省医药局在湖北沔阳主持召开了丙硫咪唑鉴定会。丙硫咪唑(albendazole)湖北省医药工业研究所于1981年开始试制,1982年以来先后经武汉,沈阳等有关医疗单位临床观察556例,疗效显著。成人顿服400mg驱鞭虫,虫卵阴转率为69.1%;驱蛔、蛲、钩虫,虫卵阴转率为96.4～100%。对297例进行血常规检查,287例进行尿常规检查,197例进行肝功能检查,服药前后无明显差异。会议经过讨论,一致认为:(1)本品合成路线简短,工艺合理,收率较高,产品质量符合临床使用标准。(2)毒性试验及临床试用结果表明,丙硫咪唑驱除蛔虫、钩虫,蛲虫、鞭虫的疗效显著。毒性低,无明显不良反应。会议建议对丙硫咪唑的制剂,用法用量,杀虫机理,使用范围以及生产中的三废治理、劳动保护等方面
On November 26-27, 1983, Hubei Provincial Science and Technology Commission and Hubei Provincial Medical Bureau hosted the albendazole identification conference in Shenyang, Hubei Province. Albendazole Hubei Institute of Pharmaceutical Industry began trial production in 1981, since 1982, Wuhan, Shenyang and other medical units clinically observed 556 cases, the effect was significant. Adult Dayton clothing 400mg whip whip bug, egg negative conversion rate of 69.1%; drive roundworm, clam, hookworm, insect egg negative conversion rate of 96.4 to 100%. 297 cases of blood tests, 287 cases of urine routine examination, 197 cases of liver function tests, before and after taking no significant difference. The meeting after discussion, agreed that: (1) The synthesis of the product line is short, reasonable process, high yield, product quality in line with clinical standards. (2) Toxicity test and clinical trial results showed that albendazole could eliminate the roundworm, hookworm, pinworm and whipworm effectively. Low toxicity, no obvious adverse reactions. The meeting suggested that albendazole preparation, dosage, insecticidal mechanism, the scope of use and production of waste management, labor protection, etc.