论文部分内容阅读
目的探讨新生儿胆红素脑病发病的临床高危因素,由此来提高临床对该病的预防和治疗能力。方法筛选从2010年1月~2013年11月在本院诊断胆红素脑病的新生儿57例(设置为脑病组),同时在该时期内筛选57例无胆红素脑病的高胆红素新生儿(设置为无脑病组),对两组新生儿的各种因素进行统计记录筛选出高危发病因素。结果脑病组新生儿体质量、12 h内发生黄疸、感染、G-6-PD缺乏以及溶血等因素和无脑病组新生儿相比,具有显著的差异(P<0.05)。结论新生儿发生胆红素脑病,可能的高危因素有:出生时体质量较低、12 h内发生黄疸、感染、存在G6PD缺乏和新生儿溶血、低蛋白血症,尤以感染和溶血性疾病为甚,因此对这些因素需要密切关注,尽可能避免高危因素的发生,从而来降低胆红素脑病的发生率。
Objective To explore the clinical risk factors of neonatal bilirubin encephalopathy, to improve the clinical prevention and treatment of the disease. Methods Fifty-seven newborns diagnosed with bilirubin encephalopathy in our hospital from January 2010 to November 2013 were selected as encephalopathy group, and 57 patients with hyperbilirubinemia without bilirubin encephalopathy Newborns (set as no encephalopathy group), the two groups of neonatal statistics of various factors to filter out the risk factors. Results There were significant differences in body mass of newborns in encephalopathy group, incidence of jaundice, infection, G-6-PD deficiency and hemolysis within 12 h compared with neonates without encephalopathy group (P <0.05). Conclusion Newborns with bilirubin encephalopathy may have high risk factors: low birth weight, jaundice and infection within 12 h, presence of G6PD deficiency and neonatal hemolysis and hypoalbuminemia, especially in infections and hemolytic diseases Therefore, these factors need close attention, as far as possible to avoid the occurrence of risk factors in order to reduce the incidence of bilirubin encephalopathy.