毛细胞性白血病(HCL)可侵犯多种器官,最常见于骨髓和脾脏,而骨侵犯和骨痛的发生率极低。三篇文献报道共284例HCL,无骨侵犯和骨痛的描述。本文作者报道一例经组织学证实为毛细胞性白血病发生骨损害,并出现对麻醉镇痛药无效的难治性骨痛,但对小至中等剂量的类固醇激素有效。女性患者,47岁,1977年出现各类血细胞减少和脾肿大,当时诊断为淋巴网状细胞病(可能为HCL),乃行脾切除,术后血细胞明显改善,脾脏组织学检查与骨髓检查所见相似,符合HCL 的诊断。1978年患者出现脊椎旁肿块及其有关的骨痛而再次住院,经局都放疗后完全缓解。1980年患者叙述颈、骨盆和上下 Hairy cell leukemia (HCL) can invade a variety of organs, most commonly in the bone marrow and spleen, while the incidence of bone invasion and bone pain is extremely low. Three articles reported a total of 284 cases of HCL, boneless invasion and bone pain described. The authors report a histologically confirmed bone loss from hairy cell leukemia and refractory bone pain that is not effective against narcotic analgesics, but is effective on small to moderate doses of steroid hormones. Female patients, 47 years of age, 1977, all kinds of cytopenia and splenomegaly, was diagnosed with lymphatic cytopathology (possibly HCL), is splenectomy, postoperative blood cells were significantly improved, spleen histological examination and bone marrow examination Similar findings, consistent with HCL diagnosis. In 1978, patients with paravertebral mass and its related bone pain were hospitalized again, and all the patients were completely relieved after radiotherapy. 1980 Patients narrated neck, pelvis and up and down