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在抗原或有丝分裂原(Mitogen)的刺激下,单核巨噬细胞和淋巴细胞都能释放可溶性因于,分别称为单核细胞因子(Monokin-e)和淋巴因子(Lymphokine)。这些因子介导细胞之间的相互作用,调节机体免疫功能的发生和发展。单核细胞因子和淋巴因子的命名一直是根据这类因子在实验中表现的生物效应及其细胞来源为基础的,由于提纯和实验的方法不同,在命名方面难免出现“同物异名”或“同名异物”的现象。为了澄清这种混乱,1979年Aarden等人①在研究了已发现的许多因子后将能在白细胞之间发挥作用的因子统一命名为白细胞间素(Interleukin,IL)。在第二届国际淋巴因子专题研讨会上,他们根据这类因子的理化特点、细胞来源和特征
Both mononuclear macrophages and lymphocytes release soluble factors due to the stimulation of antigens or mitogens (monokinok-e) and lymphokine (Lymphokine). These factors mediate the interaction between cells and regulate the occurrence and development of immune function in the body. The names of mononuclear cytokines and lymphokines have always been based on the biological effects of these factors in the experiment and the origin of their cells. Because of the different methods of purification and experimentation, naming of names is unavoidable. The phenomenon of “same foreign object”. In order to clarify this confusion, in 1979 Aarden et al.1 unified the factors that can play a role in leukocyte after studying many factors that have been discovered and named Interleukin (IL). At the 2nd International Symposium on Lymphokines, they used the physicochemical characteristics, cell sources and characteristics of these factors.