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造血生长因子(HGF)或称集落刺激因子(CSF)属于糖蛋白激素族,其作用是调节骨髓祖细胞及其子代细胞的增殖、分化、移行和细胞功能。它们也控制各种白细胞的产生。调节红细胞生成的促红细胞生成素(erythropoitin)早已熟知。但单纯调节血小板产生的调节因子尚未确定。 HGF现包括控制中性粒细胞、单核细胞和嗜酸细胞产生的激素。粒细胞集落刺激因子(G-CSF,filgrastim)和粒细胞-巨噬细胞集落刺激因子(GM-CSF,sargramostim)已在人类进行了广泛的研究,许多国家已临床使
Hematopoietic growth factors (HGFs), or colony stimulating factors (CSFs), belong to the glycoprotein hormone family and function to regulate proliferation, differentiation, migration and cell function of bone marrow progenitors and their progeny. They also control the production of various white blood cells. Erythropoietins that regulate erythropoiesis are well known. However, the regulation of platelet production by simple regulation has not yet been determined. HGF now includes hormones that control the production of neutrophils, monocytes and eosinophils. Granulocyte colony stimulating factor (G-CSF, filgrastim) and granulocyte-macrophage colony stimulating factor (GM-CSF, sargramostim) have been studied extensively in humans and many countries have clinically