1药物研究进展1·1巴比妥类是临床应用最早的第1代催眠药。按照作用时间,分为长效类,如苯巴比妥;中效类,如异戊巴比妥;短效类,如戊巴比妥、司可巴比妥;超短效类,如硫喷妥钠。由于巴比妥类药物消除缓慢,不良反应较多,安全范围较小,呼吸抑制作用和过量致死作用,长期使用可发生药 1 drug research progress 1.1 barbiturates is the earliest clinical application of the first generation of hypnotics. According to the role of time, divided into long-acting class, such as phenobarbital; moderate class, such as amobarbital; short-acting class, such as pentobarbital, Pentyl sodium. Because of the slow elimination of barbiturates, more adverse reactions, less safety margin, respiratory depression and lethal effects, long-term use can occur drugs