免疫耐受是机体对抗原的一种特殊免疫应答状态。在诱导耐受特别是在诱导外周T细胞耐受中,B细胞不仅可以分泌抗体及参与免疫调节,而且可以作为特异性的抗原提呈细胞起到重要作用。它可以活化T细胞导致免疫反应,也可以致T细胞耐受帮助诱导免疫耐受。认识B细胞如何诱导耐受可以为设计新的疗法调节自身免疫疾病和移植免疫中免疫耐受与免疫反应之间的平衡提供服务。 Immune tolerance is the body’s immune response to a special immune state. In inducing tolerance, especially in inducing peripheral T cell tolerance, B cells can not only secrete antibodies and participate in immune regulation, but also play an important role as specific antigen-presenting cells. It can activate T cells lead to immune response, can also cause T cell tolerance to help induce immune tolerance. Recognizing how B cells induce tolerance can serve the design of new therapies that regulate the balance between autoimmune diseases and immune tolerance and immune responses in transplanted immunity.