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本文报告了13例HLA/MLC配型不合的骨髓移植。所有病例至少有HLA一个位点不同,或MLC的相对反应值反复地明显地高于正常,或二者皆有。13例中有4例采用常规预防急性移植物抗宿主病(GVHD)方法,结果皆发生重度GVHD。有9例同时输注了配型不同的,胎龄4～5个月的胎肝与胸腺,其平均细胞数为9.3×10~4/kg。此9例中有8例无或仅有轻微急性GVHD(0～1度),有1例发生中度(Ⅱ度)急性GVHD。统计学方法说明所采用的新途径对预防GVHD有明显优越性。
This article reports 13 cases of HLA-MLC mismatched bone marrow transplantation. All cases had at least one HLA site different, or the MLC relative response was repeatedly significantly higher than normal, or both. Four of 13 patients underwent routine prevention of acute graft-versus-host disease (GVHD), resulting in severe GVHD. There were 9 cases of fetal liver and thymus with different type and gestational age of 4 ~ 5 months. The average number of cells was 9.3 × 10 ~ 4 / kg. Of these 9, 8 had no or only mild acute GVHD (0 to 1 degree) and 1 had moderate (grade 2) acute GVHD. Statistical methods to explain the new ways used to prevent GVHD have obvious advantages.