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目的 经动脉给药治疗成人股骨头缺血坏死,观察临床效果和影像学的变化. 方法 对60例经临床及影像学确诊为成人股骨头缺血坏死的患者,应用复方丹参、尿激酶,川芎嗪等组方介入治疗,经 1～5年的随访,观察临床效果和股骨头坏死区的影像变化. 结果 应用后患者疼痛症状减轻或消失,关节活动及行走有明显的改善,影像学表现为股骨头供血动脉分支增多、增粗,部分血管溶通;股骨头骨质破坏区边缘由模糊变清晰、硬化,破坏区内出现不规则的硬化至整个坏死区硬化,再出现骨质吸收,骨小梁塑型,呈现应力近正常骨纹理.结论 药物灌注介入治疗成人股骨头缺血坏死创伤小、操作简单、疗效快,而且效果显著.“,”Objective To observe the clinical efficacy and imaging changes of the interventional treatment for adult avascular necrosis of the femoral head. Methods Sixty patients were diagoned with avascular necrosis of the femoral head by clinical and imaging,and were treated with compound injection of red sage root/urokinase and ligustrazine hydrochloride injection during the interventional therapy. All the patients were followed up for 1～2yea rs,to oberse the clinical efficacy and imaging changes of the necroticarea. Results The pain symptom relieved or disappeared, the disorders of joint function and the travel distance were improved. DSA demonstrated that the arteries supplying the femoral head showed significant improvement.The edge of necrosis was much more clea r,and the range diminished,the vacant in femoral head showed significan t improvement.Conclusion The in terventional therapy had the advantages of little wound、simple operating and quick efficacy.