论文部分内容阅读
目的系统评价动态对比增强磁共振成像(DCE-MRI)定量灌注参数K_(trans)、K_(ep)鉴别直肠癌病理分级的价值。方法计算机检索Pub Med、EMbase、Web of Science、The Cochrane Library(2017年1期)、CBM、CNKI、VIP和Wan Fang Data数据库,搜集DCE-MRI定量灌注参数K_(trans)、K_(ep)鉴别直肠癌病理分级的文献,检索时限均为1990年到2017年2月6日。由两位评价者独立筛选文献、提取资料,并采用QUADAS-2工具评价纳入研究的偏倚风险后,采用STATA 12.0软件进行Meta分析。结果共纳入11个研究,共计618名研究对象。Meta分析结果显示:低分化组与中-高分化组间K_(trans)值差异有统计学意义[SMD=1.123,95%CI(0.334,1.911),P=0.005],而两组间K_(ep)值差异无统计学意义[SMD=0.233,95%CI(–0.173,0.639),P=0.260]。结论当前证据显示,K_(trans)可用于鉴别直肠癌病理分级,而K_(ep)的临床应用价值尚需大样本原始研究进一步验证。
Objective To evaluate the value of dynamic transplacement and K ep ephemeral perfusion (DCE-MRI) in differentiating pathological grade of rectal cancer. Methods The databases of Pub Med, EMbase, Web of Science, The Cochrane Library (2017), CBM, CNKI, VIP and Wan Fang Data were searched by computer. DCE-MRI perfusion parameters K trans and K ep Rectal cancer pathological grade of the literature, retrieval time are from 1990 to February 6, 2017. The two reviewers independently screened the literature, extracted the data, and used the QUADAS-2 tool to assess the risk of being included in the study after the meta-analysis using STATA 12.0 software. Results A total of 11 studies were included, with a total of 618 subjects. The results of Meta analysis showed that there was a significant difference in K trans between poorly differentiated and moderately differentiated patients (SMD = 1.123, 95% CI 0.334, 1.91, P = 0.005) ep) values were not significantly different [SMD = 0.233, 95% CI (-0.173, 0.639), P = 0.260]. Conclusions The current evidence shows that K trans can be used to identify the pathological grade of rectal cancer. However, the clinical value of K ep remains to be further verified by large sample original studies.