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目的 研究含氟碳气体表面活性造影剂低温保存基本特性变化 ,观察其直径大小 /浓度及二维超声回声强度。方法 将造影剂分别在室温、5℃、-5℃及 -2 0℃的条件下保存 ,保存期为 10d ,用CoulterⅡ型颗粒计数仪测定平均直径和浓度。用GELOGIQ 9超声仪二维超声观察其血管内回声强度。结果 在室温条件下造影剂可保存 2 4h ,5℃冷藏条件下能稳定 1～ 2d ,在 -5℃和 -2 0℃的条件下可保存一个月。在 -5℃和 -2 0℃条件下保存 ,第一天造影剂的浓度和二维超声血管内回声强度就开始下降 ,然而在第四天 ,造影剂的浓度及二维血管内回声强度几乎达到冷冻前的水平。结论 造影剂须在低于 -5℃的条件下保存。在融化过程中微气泡的热膨胀足以使微气泡破裂。造影剂在低温条件下保存稳定性仍不理想 ,需进一步研究提高造影剂在融化过程中保持稳定的技术 ,寻找更理想的保存方法
Objective To study the changes of basic characteristics of low-temperature preservation of contrast agent containing fluorocarbon gas and to observe its diameter size and concentration and two-dimensional ultrasonic echo intensity. Methods The contrast medium was stored under the conditions of room temperature, 5 ℃, -5 ℃ and -2 0 ℃ respectively. The storage period was 10 days. The mean diameter and concentration of the contrast agent were measured by Coulter Ⅱ Particle Counter. The intravascular echo intensity was observed by two-dimensional ultrasound with GELOGIQ 9 ultrasound system. Results The contrast agent can be stored at room temperature for 24 hours, stable at 5 ℃ for 1 ~ 2d, and stored at -5 ℃ and -2 ℃ for one month. At -5 ° C and -20 ° C, the concentration of contrast medium and the two-dimensional intravascular echo intensity decreased on the first day. On the fourth day, however, contrast medium concentration and two-dimensional intravascular echo intensity almost Reach the level before freezing. Conclusion Contrast must be stored below -5 ℃. The thermal expansion of the microbubbles during melting is sufficient to rupture the microbubbles. Contrast in the low temperature storage stability is still not ideal, need further research to improve the contrast agent in the melting process to maintain a stable technology, to find a more ideal preservation method