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近年来 ,由于抗生素广泛的、大剂量的应用 ,导致耐药菌株的产生 ;鉴于此 ,不少研究工作者正致力于开发研究新的有效控制幽门螺杆菌引发疾病的疫苗。研制Hp疫苗至关重要的问题有三种 :(1)必须发现能干扰粘附和毒性且存在于所有菌株的保护性抗原 ;(2 )临床前试验需要能模仿感染
In recent years, due to the extensive and high-dose application of antibiotics, drug-resistant strains are produced. In view of this, many researchers are devoted to developing new vaccines that effectively control Helicobacter pylori-induced diseases. There are three issues that are of crucial importance for the development of Hp vaccines: (1) protective antigens that can disrupt adherence and toxicity and that are present in all strains must be found; (2) preclinical tests need to mimic infection