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目的:探讨中药与西药联用的相互作用,促进中药的合理、安全使用。方法:通过检索近年来的文献,归纳研究方法、相互作用机制,从中西药配伍、药效学及药动学方面对中西药物相互作用进行探讨。结果:中西药物合用,药物之间可能因为配伍禁忌、药理协同、拮抗、相关代谢酶被诱导或抑制,导致疗效改变,增加或减少不良反应,甚至发生毒性反应。结论:应加强对中西药相互作用的研究。
Objective: To explore the interaction between traditional Chinese medicine and western medicine and to promote rational and safe use of traditional Chinese medicine. Methods: By searching the literature in recent years, inducing research methods and interaction mechanisms, the interaction between Chinese and western medicines was discussed from the aspects of compatibility of traditional Chinese and western medicines, pharmacodynamics and pharmacokinetics. Results: The combination of Chinese and Western medicine, drug compatibility may be due to taboo, pharmacological synergy, antagonism, related metabolic enzymes are induced or inhibited, resulting in changes in efficacy, increase or decrease in adverse reactions, and even toxic reactions. Conclusion: Interaction between Chinese and Western medicine should be strengthened.