目的 :研制低分子肝素缓释微囊。方法 :以乙基纤维素为囊材 ,正交实验设计优选制备工艺 ,用液中干燥法制备低分子肝素微囊 ,以光学显微镜观察其形态及大小分布 ,体外溶出试验研究其缓释性。结果 :所得微囊颗粒圆整 ,粒径在 10 0～ 80 0μm ,载药量为5 6 .3% ,8h累积释放百分率为 86 .6 %。结论 :所制得微囊具有良好的缓释效果 ,有良好的应用开发前景。 Objective: To develop low molecular weight heparin sustained-release microcapsules. Methods: Ethylcellulose was used as the material and orthogonal design was adopted to optimize the preparation process. The low molecular weight heparin microcapsules were prepared by liquid drying method. The morphology and size distribution were observed under light microscope. The dissolution in vitro was also studied. Results: The obtained microcapsule particles were round and the particle size was 100 ~ 80μm. The drug loading was 56.3%, and the cumulative release percentage was 86.6% after 8 hours. Conclusion: The prepared microcapsules have good sustained-release effect and good prospect of application and development.