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目的:研究芎冰微乳制剂在兔体内的药动学特征。方法:芎冰微乳质量静脉注射给药后,采用高效液相测定不同时间点TMP的血药浓度,用DAS2.1数据处理软件计算药动学参数。结果:TMP体内质量浓度在0.062～12.4 mg.L-1(R2=0.998)呈良好的线性关系,其血药浓度曲线符合二室模型,其主要药动学参数t1/2α=15.617 mint,1/2β=49.171 min,V=0.509 L.kg-1,CL=0.014 L.min-1.kg-1,AUC(0-∞)=222 063.235μg.min.L-1,MRT(0-∞)=30.841 min。结论:本实验建立的方法简单,线性、精密度、回收率良好,专属性强,可用于川芎嗪体内药动学研究,并明确了芎冰微乳注射给药在新西兰兔体内的药动学特征。
Objective: To study the pharmacokinetics of Xiongxiong microemulsion in rabbits. Methods: After intravenous injection of Xiongxiong micro-emulsion, the plasma concentrations of TMP at different time points were measured by HPLC. Pharmacokinetic parameters were calculated by DAS2.1 data processing software. RESULTS: The concentration of TMP in vivo was linear between 0.062 ~ 12.4 mg.L-1 (R2 = 0.998). The plasma concentration curve of TMP was in accordance with the two-compartment model. The main pharmacokinetic parameters were t1 / 2α = 15.617 mint, 1 / 2β = 49.171 min, V = 0.509 L.kg-1, CL = 0.014 L.min-1.kg-1, AUC0- ∞ = 222 063.235 μg.min.L-1, MRT (0-∞ ) = 30.841 min. Conclusion: The method established in this experiment is simple, linear, precision, good recovery, specificity, can be used for pharmacokinetic studies of ligustrazine in vivo, and clear pharmacokinetics of Xiong Bing microemulsion injection in New Zealand rabbits feature.