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磷酸氯喹是一种合成药,和奎宁一样有抗疟性,其分子式颇相似。磷酸氯喹从消化道几乎完全被吸收,迅即达到高的血浆浓度,仅极少量药物被排泄,故可在组织内蓄积;停药后,从组织中消失很缓慢。磷酸氯喹在全世界广泛使用已30多年。通常是在大剂量的、长期使用后有少数病人可发生神经性聋;1978年本文作者等曾报告68例药物引起的耳聋中有14例系由用氯喹治疗引起,均为双侧严重的感觉神经性聋,语言频率损失超过60dB。以前认为这种耳聋不能恢复。
Chloroquine phosphate is a synthetic drug, as anti-malarial quinine, its formula is quite similar. Chloroqui phosphate is almost completely absorbed from the digestive tract, reaching a high plasma concentration, only a very small amount of drug is excreted, it can accumulate in the tissue; withdrawal, disappear from the tissue is very slow. Chloroqui phosphate is widely used in the world for more than 30 years. Usually in high-dose, long-term use of a small number of patients with neurological deafness; 1978 authors have reported 68 cases of drug-induced deafness in 14 cases caused by treatment with chloroquine, are bilateral severe feeling Nervous deafness, language frequency loss of more than 60dB. I used to think that this kind of deafness can not be restored.