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为探讨使用西米替丁对肾病患儿肌酐清除率 (Ccr)的影响 ,将53例肾小球疾病患儿分为两组 :A组28例Ccr≥80ml/(min·1.73m2)和B组25例Ccr<80ml/(min·1.73m2)。观察对象实验当天分别留7a.m.～9a.m.和10a.m.～12a.m.尿,测2小时尿肌酐 ;9am抽血测血肌酐 ,并口服西米替丁0.8g/1.73m2。分别计算服药前、后2小时肌酐清除率 (Ccr1、Ccr2)并行统计分析。结果发现两组患儿Ccr2均较Ccr1显著降低 (P<0.05) ,但A组患儿 (Ccr1 -Ccr2)的均数与同组Ccr2均数的比值仅为3.9% ;B组患儿 (Ccr1 -Ccr2)的均数与同组Ccr2均数的比值则为103.4 %。对数回归示 ,(Ccr1 -Ccr2)/Ccr2与Ccr2呈显著负相关 ,(r= -0.791 ,P<0.05)。提示对肾功能不全患儿可用服西米替丁后的Ccr评价其肾功能。
To investigate the effect of cimetidine on creatinine clearance (Ccr) in children with nephropathy, 53 children with glomerular disease were divided into two groups: group A, 28 patients with Ccr≥80ml / (min · 1.73m2) and B Group Ccr <80ml / (min · 1.73m2). Observed the day of the experiment were left 7 a.m. ~ 9a.m. And 10 a.m. ~ 12a.m. Urine, measured 2 hours urine creatinine; 9am blood test serum creatinine and oral cimetidine 0.8g / 1.73 m2. Calculate the creatinine clearance rate (Ccr1, Ccr2) statistical analysis before and 2 hours after taking medicine. The results showed that Ccr2 in both groups was significantly lower than that in Ccr1 (P <0.05), but the average ratio of Ccr1-Ccr2 in group A to that in Ccr2 was only 3.9% -Ccr2) and the same group Ccr2 average ratio was 103.4%. Log regression showed (Ccr1 -Ccr2) / Ccr2 negative correlation with Ccr2 (r = -0.791, P <0.05). Prompt renal insufficiency children with ciclbirubine Ccr assessment of renal function.