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乙型肝炎病毒 (ｈｅｐａｔｉｔｉｓＢｖｉｒｕｓ ,ＨＢＶ)的慢性感染与肝细胞癌 (ｈｅｐａｔｏｃｅｌｌｕｌａｒｃａｒｃｉｎｏｍａ,ＨＣＣ)的发生密切相关 ,但目前对其机制仍不清楚。以往的研究表明 ,ＨＢＶ的转录活化蛋白ＨＢｘ通过与肿瘤抑制蛋白ｐ5 3结合参与肝细胞癌的发
Chronic infection with hepatitis B virus (HBV) is closely related to the occurrence of hepatocellular carcinoma (HCC), but its mechanism remains unclear at present. Previous studies have shown that HBV transcriptional activation protein HBx is involved in the development of hepatocellular carcinoma by binding to the tumor suppressor protein p5 3