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目的探讨成功根除幽门螺杆菌（Ｈｐ）感染后，胃粘膜组织学及多胺（腐胺、精脒和精胺）含量变化的意义．方法Ｈｐ阳性患者５６例，其中男３９例，女１７例；胃溃疡７例，十二指肠溃疡１８例，慢性胃炎３１例．根除Ｈｐ前和根除治疗４ｗｋ～６ｗｋ后胃粘膜多胺含量及其组织学变化，同时设Ｈｐ阴性患者２０例作对照．结果Ｈｐ阳性患者胃窦粘膜蛋白多胺含量（μｍｏｌ／ｇ）明显高于阴性患者（腐胺０９６±０４９ｖｓ０４１±０３１，精脒２０１±０４８ｖｓ０８３±０３７，精胺２５８±０５７ｖｓ１３３±０４２，Ｐ＜００１）．Ｈｐ根除后就显著下降（腐胺０４８±０４０ｖｓ０９４±０４２，精脒１１１±０３４ｖｓ１９８±０３９，精胺１５３±０５５ｖｓ２６６±０４４，Ｐ＜００５）．胃窦部粘膜腐胺和精脒含量高于胃体部（腐胺０９９±０３１ｖｓ０５９±０２４，精脒２０７±０３８ｖｓ１３０±０３４，Ｐ＜００５）．组织学检查显示根除Ｈｐ感染后炎细胞浸润程度明显降低．结论根除Ｈｐ感染能够降低胃粘膜的增殖活性，从而降低胃癌的危险性．
Objective To investigate the significance of gastric mucosal histology and changes of polyamines (putrescine, spermidine and spermine) after successful eradication of Helicobacter pylori (Hp) infection. Methods 56 cases of Hp positive patients, including 39 males and 17 females; gastric ulcer in 7 cases, duodenal ulcer in 18 cases, 31 cases of chronic gastritis. Gastric mucosa polyamines content and histological changes were observed before and after eradication of Hp for 4wk ~ 6wk, and 20 Hp-negative patients were used as controls. Results Antral mucosal protein polyamine content (μmol / g) in Hp positive patients was significantly higher than that in negative patients (096 ± 049 vs041 ± 031, spermine 201 ± 048 vs083 ± 037, spermine 258 ± 057vs133 ± 042, P <001). Hp significantly decreased after eradication (putrescine 0 48 ± 0 40vs0 94 ± 0 42, spermine 1 11 ± 0 34vs1 98 ± 0 39, spermine 1 53 0 55 2. 66 ± 044, P <005). The content of putrescine and spermine in the gastric antrum was higher than that in the gastric body (099 ± 031 vs059 ± 024, spermine 207 ± 038vs130 ± 034, P < 0 05). Histological examination showed that the degree of infiltration of inflammatory cells was significantly reduced after Hp eradication. Conclusion Eradication of Hp infection can reduce gastric mucosal proliferative activity and thus reduce the risk of gastric cancer.