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目的探讨粘结合蛋白多糖-1(Syndecan-1)、甲壳质酶蛋白40(YKL-40)和骨桥蛋白(OPN)在子宫内膜异位症患者中的表达及意义。方法选择2015年1月-2016年6月经病理学检查诊断为子宫内膜异位症的78例患者为子宫内膜异位症组,选择同期行健康体检的30例女性为对照组。两组女性入院后进行子宫内膜异位症分期和痛经评分。检测两组女性血清Syndecan-1、YKL-40和OPN水平,不同月经周期、分期和痛经评分的子宫内膜异位症组患者血清Syndecan-1、YKL-40和OPN水平,观察子宫内膜异位症组患者血清Syndecan-1水平、YKL-40水平和OPN水平之间的相关性。结果子宫内膜异位症组患者血清Syndecan-1、YKL-40和OPN水平均明显高于对照组,差异均有统计学意义(均P<0.05)。增生期患者血清Syndecan-1、YKL-40和OPN水平明显高于分泌期患者,差异均有统计学意义(均P<0.05)。子宫内膜异位症患者血清Syndecan-1、YKL-40和OPN水平随着痛经分期的增加而升高(P<0.05)。子宫内膜异位症患者血清Syndecan-1、YKL-40和OPN水平随着痛经评分增加而升高(P<0.05)。子宫内膜异位症患者血清Syndecan-1水平、YKL-40水平与血清OPN水平呈正相关,血清Syndecan-1水平和血清YKL-40水平呈正相关。结论 Syndecan-1、YKL-40和OPN参与了子宫内膜异位症的发生、发展过程,各指标之间相互呈正相关,联合检测对于诊断疾病和病情评估有重要的临床意义。
Objective To investigate the expression and significance of Syndecan-1, YKL-40 and OPN in patients with endometriosis. Methods From January 2015 to June 2016, 78 patients diagnosed as endometriosis by pathology were endometriosis patients, and 30 women who underwent physical examination in the same period were selected as the control group. Two groups of women were admitted to hospital for endometriosis staging and dysmenorrhea score. Serum levels of Syndecan-1, YKL-40 and OPN were measured in patients with endometriosis with different serum levels of Syndecan-1, YKL-40 and OPN, menstrual cycle, staging and dysmenorrhea scores. Syndecan-1 serum levels, YKL-40 levels and OPN levels in patients with symptomatic disease. Results The serum levels of Syndecan-1, YKL-40 and OPN in patients with endometriosis were significantly higher than those in the control group (all P <0.05). Syndecan-1, YKL-40 and OPN in patients with proliferative phase were significantly higher than those in secretory phase (all P <0.05). Serum levels of Syndecan-1, YKL-40 and OPN in patients with endometriosis increased with the increase of dysmenorrhea stage (P <0.05). Serum levels of Syndecan-1, YKL-40 and OPN in patients with endometriosis increased with the increase of dysmenorrhea score (P <0.05). Serum levels of Syndecan-1 and YKL-40 in patients with endometriosis were positively correlated with serum OPN levels, and there was a positive correlation between serum Syndecan-1 levels and serum YKL-40 levels. Conclusions Syndecan-1, YKL-40 and OPN are involved in the pathogenesis and development of endometriosis. There is a positive correlation between each index, and joint detection is of great clinical significance for the diagnosis of disease and condition.