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目的分析降钙素原在新生儿败血症早期诊断中的临床价值。方法选取2014年7月-2015年10月南京中医药大学附属中西医结合医院新生儿科收治的疑似败血症患儿44例为研究组,另选取同期出生的健康新生儿44例为对照组。分析两组新生儿的血清降钙素原水平,比较研究组患儿治疗前后血清降钙素原水平。结果治疗前,研究组血清降钙素原水平为(5.08±1.74)ng/ml,显著高于对照组的(0.11±0.04)ng/ml,差异有统计学意义(t=18.958,P<0.05);共诊断新生儿败血症36例(含临床败血症),降钙素原阳性预测值为85.71%,优于白细胞计数和血小板计数。治疗后,患儿降钙素原水平较治疗前显著降低,差异有统计学意义(t=28.924,P<0.05)。结论新生儿败血症患儿血清降钙素原水平较健康患儿显著升高,其阳性预测值较高,敏感度较好,可作为新生儿败血症的早期预测指标,有利于新生儿败血症的早期诊断、早期治疗及改善预后。
Objective To analyze the clinical value of procalcitonin in the early diagnosis of neonatal sepsis. Methods From July 2014 to October 2015, 44 children with suspected septicemia admitted to Department of Neonatology, Affiliated Integrative Medicine Hospital, Nanjing University of Traditional Chinese Medicine were selected as study group. Another 44 healthy newborns were selected as control group. The levels of serum procalcitonin in two groups of newborns were analyzed. The levels of serum procalcitonin before and after treatment in the study group were compared. Results Before treatment, the level of procalcitonin in the study group was (5.08 ± 1.74) ng / ml, which was significantly higher than that in the control group (0.11 ± 0.04) ng / ml, the difference was statistically significant (t = 18.958, P <0.05 ); A total of 36 cases of neonatal sepsis (including clinical sepsis) were diagnosed, the positive predictive value of procalcitonin was 85.71%, which was better than the white blood cell count and platelet count. After treatment, children with procalcitonin levels were significantly lower than before treatment, the difference was statistically significant (t = 28.924, P <0.05). Conclusions Serum procalcitonin levels in neonates with septicemia were significantly higher than those in healthy children, with higher positive predictive value and better sensitivity, which could be used as an early predictor of neonatal sepsis and be helpful for the early diagnosis of neonatal sepsis , Early treatment and improve prognosis.