论文部分内容阅读
目的观察复方氨基酸和丹参注射液联合治疗胎儿生长受限(FGR)的临床疗效。方法随机将48例因FGR入院治疗的患者分成2组:观察组25例给予丹参注射液20ml加入5%葡萄糖注射液250ml和复方氨基酸注射液500ml静脉滴注,日1次;对照组23例给予复方氨基酸注射液500ml静脉滴注,日1次;2组均以10天为1疗程,间隔1周后,可再继续下一疗程。治疗期间定期用B型超声监测两组胎儿生长发育参数,产后测量新生儿出生体重。二组进行比较,比较治疗前后宫高增长,胎儿双顶径,股骨长情况及脐血流S/D比值,比较新生儿的出生体重。结果治疗后检查,观察组每周增长:宫高(1.31±0.38)cm、双顶径(2.78±0.60)mm、股骨长(2.22±0.57)mm、脐血流S/D比值(2.32±0.42)、新生儿出生体重(3047±236)g;对照组:宫高(1.12±0.16)cm、双顶径(2.37±0.42)mm、股骨长(1.56±0.41)mm、脐血流S/D比值(2.94±0.58)、新生儿出生体重(2437±279)g。两组间比较,观察组在宫高增长显著高于对照组(P<0.05)、胎儿双顶径及股骨长增长、新生儿体重均显著高于对照组(P<0.01),脐血流S/D比值显著低于对照组(P<0.01)。结论丹参和氨基酸联合用药较单独应有氨基酸更有效改善子宫胎盘血液供应,及治疗FGR,促进胎儿的生长。
Objective To observe the clinical effect of compound amino acid and Salvia miltiorrhiza injection on fetal growth restriction (FGR). Methods Forty-eight patients admitted to hospital for FGR were randomly divided into 2 groups: 25 cases in observation group were given Danshen injection 20ml, 250ml of 5% glucose injection and 500ml of compound amino acid injection, once daily and 23 cases in control group Compound amino acid injection 500ml intravenous infusion, 1 day; 2 groups were 10 days for a course of treatment, an interval of 1 week, you can continue the next course of treatment. Regular treatment with B-mode ultrasound monitoring of fetal growth and development parameters of two groups, postpartum birth weight measurement of newborns. The two groups compared before and after treatment, high growth rate of the uterus, fetal biparietal diameter, femur length and umbilical blood flow S / D ratio, the birth weight of newborns. Results After the treatment, the observation group had a weekly increase in the height (1.31 ± 0.38) cm, biparietal diameter (2.78 ± 0.60) mm, femur length (2.22 ± 0.57) mm and cord blood flow S / D ratio ), Birth weight (3047 ± 236) g in newborns, and control group (1.12 ± 0.16 cm in height, 2.37 ± 0.42 mm in diameter, 1.56 ± 0.41 mm in femur, S / D Ratio (2.94 ± 0.58), newborn birth weight (2437 ± 279) g. Compared with the control group (P <0.05), the biparietal diameter and the length of the femur of the observation group were significantly higher than those of the control group (P <0.01). The cord blood flow S / D ratio was significantly lower than the control group (P <0.01). Conclusion Salvia miltiorrhiza combined with amino acids can improve blood supply of uterine placenta more effectively than single amino acids alone, and can treat FGR and promote fetal growth.