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1983年国际化合物安全性计划(IPCS)在离体短期测试的联合研究中得到的重要结论之一是“急需确立判断测试结果为阳性或阴性的标准”。完成此任务后的细胞遗传学测试具有很大的优越性,因为这些测试已积累了许多经验,同时它们在肿瘤检测方面又是Ames测试的一种补充。最近,Galloway等用中国仓鼠卵细胞(CHO)进行离体细胞遗传学测试的改进方法,其中简要介绍了对姐妹染色单体交换(SCE)和染色体畸变测试的新统计分析
One of the important conclusions reached in the joint study of the International Compound Safety Program (IPCS) in 1983 on short-term in vitro tests was the “urgent need to establish criteria for judging positive or negative test results.” Cytogenetics testing after this task has great advantages as these tests have accumulated a wealth of experience and they are complementary to the Ames test in tumor detection. Recently, Galloway et al., An improved method for ex vivo cytogenetic testing using Chinese hamster ovary cells (CHO), outlines a new statistical analysis of sister chromatid exchange (SCE) and chromosomal aberration tests