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在云南西南部抗氯喹恶性疟流行区,用磷酸咯萘啶(咯)1000mg、磺胺多辛(磺)1000mg和伯喹(伯)45mg治疗恶性疟62例;咯1250mg、磺1250mg与伯56.25mg治疗20例;咯1200mg、磺1500mg与伯67.5mg治疗34例,进行比较观察,三组即时疗效相似,三组治疗后28d内的复燃率分别为15.5％、5.9％及8.7％;治疗后7d内的配子体清除率分别为66.7％、100％及100％,三组间有高度显著性差异。结果提示三药伍用治疗抗氯喹恶性疟时,咯萘啶总量不宜少于1200mg;伯喹不宜少于56.25mg。
62 cases of P. falciparum were treated with 1000 mg of pyronaridine phosphate and 1000 mg of sulfadoxine and 45 mg of primary quercetin in Southwest Yunnan. Treatment of 20 cases; slightly 1200mg, 1500mg sulfone and 67.5mg treatment of 34 cases were compared and observed the immediate effect of the three groups were similar, three groups within 28d after the resuscitation were 15.5%, 5.9% and 8.7%; after treatment The clearance rate of gametophytes in 7d was 66.7%, 100% and 100%, respectively, with highly significant differences among the three groups. The results suggest that triple drug treatment of chloroquine-resistant falciparum malaria, pyronaridine total should not be less than 1200mg; primaquine should not be less than 56.25mg.