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目的了解临沂市人群百日咳抗体水平及流行特征,为预测疫情趋势和制定免疫策略提供依据。方法对临沂市1956～2012年不同免疫阶段百日咳发病资料进行描述性分析;在不同年份随机抽取健康人群,分0～、2～、5～、8～、11～、15～、20～40岁7个年龄组进行百日咳抗体检测。结果 1956～2012年临沂市共报告百日咳578 487例,死亡426例。大致分为4个阶段:1956～1960年年均发病率为86.60/10万,死亡127例;1961～1981年年均发病率为283.82/10万,死亡296例;1982～2002年年均发病率为9.75/10万,死亡3例;2003～2012年年均发病率为0.16/10万,无死亡病例。1986～2012年共检测4 556人,达到抗体保护水平的3 587人,保护率为78.73%,几何平均滴度(GMT)为1∶197.24。结论已实施的免疫策略对控制百日咳发病效果显著,发病率大幅度降低;人群保护率和抗体水平有逐年增高趋势,说明疫苗接种工作质量较高;应警惕大年龄组儿童和成人百日咳的出现和传播。
Objective To understand the prevalence and prevalence of pertussis antibodies in the population of Linyi and provide evidence for predicting the epidemic trend and formulating immunization strategies. Methods Descriptive analysis of the incidence of pertussis in different stages of immunization from 1956 to 2012 in Linyi City. The healthy people were randomly selected in different years and divided into 0 ~, 2 ~, 5 ~, 8 ~, 11 ~, 15 ~, 20 ~ 40 years old 7 age group for pertussis antibody test. Results A total of 578 487 pertussis patients were reported in Linyi City from 1956 to 2012, with 426 deaths. It is roughly divided into four stages: the average annual incidence was 86.60 / 100,000 from 1956 to 1960, with 127 deaths; the average annual incidence was 283.82 / 100,000 from 1961 to 1981, with 296 deaths; and the average annual incidence was from 1982 to 2002 The rate was 9.75 / 100 000, with 3 deaths. The average annual incidence from 2003 to 2012 was 0.16 / 100 000 with no deaths. A total of 4 556 people were detected from 1986 to 2012, reaching 3 587 of the antibody protection level, with a protection rate of 78.73% and a geometric mean titer (GMT) of 1: 197.24. Conclusion The immunization strategy has a significant effect on the control of pertussis, the incidence rate is significantly reduced. The population protection rate and antibody level are increasing year by year, which indicates the high quality of vaccination work. The emergence of pertussis in children and adults of large age group should be vigilant. spread.