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无嘌呤/无嘧啶核酸内切酶(apurinic/apyrimidinic endonuclase,APE/Ref-1)是人体内一种重要的多功能蛋白,它涉及细胞凋亡、肿瘤发生、神经系统退行性变等病理过程[1-3]。目前大量研究表明,APE/Ref-1与多种肿瘤的发生、发展和预后相关。碳酸酐酶Ⅸ(carbonic anhydraseⅨ,CAⅨ)是分布于细胞膜和细胞核的糖蛋白,是碳酸酐酶家族中的一种同工酶,参与呼吸、酸碱平衡、骨吸收、眼睛房水形成等机体内的多种生物
Apurinic / apyrimidinic endonuclease (APE / Ref-1) is an important multifunctional protein in the human body and it is involved in the pathological processes such as apoptosis, tumorigenesis and nervous system degeneration [ 1-3]. At present, a large number of studies have shown that APE / Ref-1 is associated with the occurrence, development and prognosis of various tumors. Carbonic anhydrase IX (CAIX) is a glycoprotein distributed in the cell membrane and nucleus. It is an isoenzyme in the carbonic anhydrase family. It participates in respiration, acid-base balance, bone resorption, and formation of aqueous humor A variety of creatures