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急性冠状动脉闭塞后局部心肌的氧供需平衡是心肌损伤大小的决定性因素。血管扩张剂通过其血液动力学作用,有可能改善这一平衡。潘生丁是一强力的血管扩张剂,同时还有强力的抗血栓作用。本文评价潘生丁对缩小实验性急性冠状动脉闭塞后心肌梗塞大小的作用。方法:12只狗,在戊巴比妥麻醉、气管插管下剖胸,结扎左冠状动脉前降支,用心脏表面心电图标测法估计梗塞的范围。冠状动脉结扎前和结扎后,定期记录血压、心率和左心室舒张末期压。将结扎后15分钟心脏表面心电图标测显示同等程度ST段
The oxygen supply and demand balance of local myocardium after acute coronary occlusion is the decisive factor of myocardial injury. Vasodilators, through their hemodynamic effects, may improve this balance. Dipyridamole is a potent vasodilator and has a potent antithrombotic effect. This article evaluates the role of dipyridamole in reducing the size of myocardial infarction after experimental acute coronary occlusion. Methods: Twelve dogs were deprived of thoracotomy under pentobarbital anesthesia and endotracheal intubation, and the anterior descending branch of left anterior descending coronary artery was ligated. The infarct size was estimated by the method of cardiac surface electrocardiogram. Before coronary artery ligation and ligation, blood pressure, heart rate and left ventricular end-diastolic pressure were recorded regularly. 15 minutes after ligation of the heart surface ECG showed the same degree of ST segment