论文部分内容阅读
目的探讨胃癌手术前后腹腔冲洗液CEA、CA199的变化及其临床诊断价值。方法采用电化学发光免疫方法对我市人民医院2006年1月～2009年1月收治的60例胃癌患者及40例胃部良性病变患者检测其手术前后腹腔冲洗液中的CEA、CA199的变化。结果治疗组的血清CEA、CA199水平均显著高于对照组(P<0.05),治疗组术后的血清CEA、CA199水平均显著低于术前(P<0.05);两项联合检测的敏感性及准确性均显著高于CEA、CA199的单项检测的结果(P<0.05)。结论血清CEA、CA199水平变化对胃癌的临床诊断及疗效评价具有重要的临床价值,同时也有助于指导术后治疗及预测患者术后有无复发和转移。
Objective To investigate the changes of CEA and CA199 in peritoneal washings before and after gastric cancer operation and its clinical value. Methods Electrochemiluminescence immunoassay was used to detect the changes of CEA and CA199 in peritoneal washings before and after surgery in 60 patients with gastric cancer and 40 patients with benign gastric lesions admitted to our hospital from January 2006 to January 2009. Results The serum levels of CEA and CA199 in the treatment group were significantly higher than those in the control group (P <0.05), and the levels of CEA and CA199 in the treatment group were significantly lower than those before the operation (P <0.05). The sensitivity of the two combined tests And the accuracy was significantly higher than the CEA, CA199 single test results (P <0.05). Conclusion The changes of serum CEA and CA199 levels have important clinical value in clinical diagnosis and evaluation of gastric cancer. They also help to guide the postoperative treatment and predict the recurrence and metastasis of the patients.