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再狭窄是限制冠状动脉内支架术远期成功的重要因素。它是一个由内皮损伤触发的多种因子参与的损伤修复过程,主要包括:机械损伤内皮处非阻塞性血栓形成、新生内膜增生及血管重构等反应。E-选择素仅表达于活化的内皮细胞表面,主要作用是在炎症发生时介导白细胞与血管内皮细胞的起始黏附,以及介导白细胞之间、白细胞与血小板之间的黏附形成血栓,从而对支架置入后损伤的内膜增生过程产生影响。E-选择素的研究对揭示再狭窄发生机制及寻找新的治疗途径均具有重要意义。
Restenosis is an important factor that limits the long-term success of coronary stenting. It is involved in a variety of factors triggered by endothelial injury injury repair process, including: mechanical injury at the endothelium of non-obstructive thrombosis, neointimal hyperplasia and vascular remodeling and other reactions. E-selectin is expressed only on the surface of activated endothelial cells, the main role of which is to mediate the initial adhesion of leukocytes to vascular endothelial cells upon inflammation and to mediate the adhesion between leukocytes, leukocytes and platelets to form thrombus Impact on intimal hyperplasia after injury of stent implantation. E-selectin research to reveal the mechanism of restenosis and find new therapeutic pathways are of great significance.