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目的对苯甲酸雌二醇联合米非司酮及米索前列醇片在稽留流产中的应用观察。方法将稽留流产患者分为二组:A组:肌注苯甲酸雌二醇同时口服米非司酮及米索前列醇片,必要时行钳刮术或清宫术。B组:肌注苯甲雌二醇3～5天后直接行钳刮术或清宫术。结果A组完全流产率为6.45%,B组完全流产率为0。A组宫颈扩张满意达89.52%,B组宫颈扩张满意达8.51%。结论患者联合用药后可诱导流产,有利于宫颈软化和宫口扩张,提高子宫肌的敏感性,使钳刮术或清宫术趋于简单、快捷,减轻患者痛苦,减少并发症。苯甲酸雌二醇联合米非司酮及米索前列醇片应用于稽留流产明显优于注射苯甲酸雌二醇后直接钳刮或清宫术。
Objective To observe the application of estradiol benzoate combined with mifepristone and misoprostol in missed abortion. Methods The patients with missed abortion were divided into two groups: group A: intramuscular injection of estradiol benzoate while oral mifepristone and misoprostol tablets, if necessary, forceps curettage or curettage. Group B: intramuscular benzoestradiol 3 to 5 days after the line directly curettage or curettage. Results The complete abortion rate was 6.45% in group A and 0 in group B. A group of cervical dilatation satisfaction reached 89.52%, B group cervical dilatation satisfaction reached 8.51%. Conclusions Patients can induce miscarriage after combined treatment, which is good for cervix softening and cervix expansion and enhancing the sensitivity of uterine muscle. It makes the forceps curettage or curettage simple and quick, reduces patient ’s pain and reduces the complication. Estradiol benzoate combined with mifepristone and misoprostol tablets used in missed abortion was significantly better than injection of estradiol benzoate direct clamp curettage or curettage.