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目的:探讨阿莫西林联合甲强龙治疗老年支气管肺炎患者的临床效果及其可能的作用机制。方法:选取我院呼吸科收治的老年支气管肺炎患者84例,根据治疗方案不同分为常规组及试验组。比较两组患者治疗前后临床体征、Ig A、Ig M、Ig G、CD4+及CD8+T淋巴细胞、NK细胞及血清LDH3、LDH4、HBDH水平的变化情况。结果:治疗后,试验组咳喘、高热、肺内干湿罗音的恢复时间明显短于常规组,Ig A、Ig M、Ig G、LDH、HBDH、NK细胞及CD8+T淋巴细胞水平明显低于常规组,CD4+T淋巴细胞水平明显高于常规组,差异均具有统计学意义(P<0.05)。结论:阿莫西林联合甲强龙可有效快速改善老年支气管肺炎患者的临床症状,这可能与其降低Ig A、Ig M、Ig G、LDH、HBDHNK细胞及CD8+T淋巴细胞水平及提高CD4+T淋巴细胞水平有关。
Objective: To investigate the clinical effect and its possible mechanism of amoxicillin combined with methylprednisolone in the treatment of elderly patients with bronchial pneumonia. Methods: Eighty-four elderly patients with bronchopneumonia admitted to our department were divided into routine group and experimental group according to different treatment regimens. The changes of clinical signs, Ig A, Ig M, Ig G, CD4 +, CD8 + T lymphocytes, NK cells and serum LDH3, LDH4 and HBDH before and after treatment were compared between the two groups. Results: After treatment, the recovery time of cough and fever in the experimental group was significantly shorter than that in the conventional group, and IgA, Ig M, Ig G, LDH, HBDH, NK cells and CD8 + T lymphocytes in the experimental group The level of CD4 + T lymphocytes was significantly lower than that of the conventional group, the difference was statistically significant (P <0.05). Conclusion: Amoxicillin combined with methylprednisolone can effectively and rapidly improve the clinical symptoms of elderly patients with bronchial pneumonia, which may be related to its ability to reduce Ig A, Ig M, Ig G, LDH, HBDHNK and CD8 + T lymphocyte levels and increase CD4 + T Lymphocyte level related.